Faculty: Amber Simpson, PhD

Faculty: Amber Simpson, PhD


Profile:

Dr. Simpson is an Assistant Attending Computational Biologist in the Hepatopancreatobiliary Service in the Department of Surgery at Memorial Sloan-Kettering (MSK) Cancer Center in New York. Her research lab specializes in computer-aided surgery and medical image processing; her research group is focused on developing novel computing strategies for precision oncology. She joined the MSK faculty in January 2015 after three years as a Research Assistant Professor in Biomedical Engineering at Vanderbilt University. She received her PhD in Computer Science from Queen’s University in Kingston, Ontario, Canada.


Publications:

  1. Yamashita, R, Perrin, T, Chakraborty, J, Chou, JF, Horvat, N, Koszalka, MA et al.. Radiomic feature reproducibility in contrast-enhanced CT of the pancreas is affected by variabilities in scan parameters and manual segmentation. Eur Radiol. 2019; :. doi: 10.1007/s00330-019-06381-8. PubMed PMID:31392481 .
  2. Golia Pernicka, JS, Gagniere, J, Chakraborty, J, Yamashita, R, Nardo, L, Creasy, JM et al.. Radiomics-based prediction of microsatellite instability in colorectal cancer at initial computed tomography evaluation. Abdom Radiol (NY). 2019; :. doi: 10.1007/s00261-019-02117-w. PubMed PMID:31250180 .
  3. Attiyeh, MA, Chakraborty, J, McIntyre, CA, Kappagantula, R, Chou, Y, Askan, G et al.. CT radiomics associations with genotype and stromal content in pancreatic ductal adenocarcinoma. Abdom Radiol (NY). 2019;44 (9):3148-3157. doi: 10.1007/s00261-019-02112-1. PubMed PMID:31243486 PubMed Central PMC6692205.
  4. Wang, T, Drill, E, Vakiani, E, Pak, LM, Boerner, T, Askan, G et al.. Distinct histomorphological features are associated with IDH1 mutation in intrahepatic Cholangiocarcinoma. Hum. Pathol. 2019; :. doi: 10.1016/j.humpath.2019.05.002. PubMed PMID:31121195 .
  5. Pak, LM, Gagnière, J, Allen, PJ, Balachandran, VP, D'Angelica, MI, DeMatteo, RP et al.. Utility of Image Guidance in the Localization of Disappearing Colorectal Liver Metastases. J. Gastrointest. Surg. 2019;23 (4):760-767. doi: 10.1007/s11605-019-04106-2. PubMed PMID:30680630 .
  6. Speers, AD, Ma, B, Jarnagin, WR, Himidan, S, Simpson, AL, Wildes, RP et al.. Fast and accurate vision-based stereo reconstruction and motion estimation for image-guided liver surgery. Healthc Technol Lett. 2018;5 (5):208-214. doi: 10.1049/htl.2018.5071. PubMed PMID:30464852 PubMed Central PMC6222177.
  7. Narayan, RR, Creasy, JM, Goldman, DA, Gönen, M, Kandoth, C, Kundra, R et al.. Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations. Cancer. 2019;125 (4):575-585. doi: 10.1002/cncr.31850. PubMed PMID:30427539 PubMed Central PMC6636637.
  8. Chakraborty, J, Midya, A, Gazit, L, Attiyeh, M, Langdon-Embry, L, Allen, PJ et al.. CT radiomics to predict high-risk intraductal papillary mucinous neoplasms of the pancreas. Med Phys. 2018;45 (11):5019-5029. doi: 10.1002/mp.13159. PubMed PMID:30176047 .
  9. Attiyeh, MA, Chakraborty, J, Gazit, L, Langdon-Embry, L, Gonen, M, Balachandran, VP et al.. Preoperative risk prediction for intraductal papillary mucinous neoplasms by quantitative CT image analysis. HPB (Oxford). 2019;21 (2):212-218. doi: 10.1016/j.hpb.2018.07.016. PubMed PMID:30097414 PubMed Central PMC6367060.
  10. Sigel, CS, Drill, E, Zhou, Y, Basturk, O, Askan, G, Pak, LM et al.. Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns. Am. J. Surg. Pathol. 2018;42 (10):1334-1345. doi: 10.1097/PAS.0000000000001118. PubMed PMID:30001234 PubMed Central PMC6657522.
  11. Creasy, JM, Midya, A, Chakraborty, J, Adams, LB, Gomes, C, Gonen, M et al.. Quantitative imaging features of pretreatment CT predict volumetric response to chemotherapy in patients with colorectal liver metastases. Eur Radiol. 2019;29 (1):458-467. doi: 10.1007/s00330-018-5542-8. PubMed PMID:29922934 PubMed Central PMC6301122.
  12. Perrin, T, Midya, A, Yamashita, R, Chakraborty, J, Saidon, T, Jarnagin, WR et al.. Short-term reproducibility of radiomic features in liver parenchyma and liver malignancies on contrast-enhanced CT imaging. Abdom Radiol (NY). 2018;43 (12):3271-3278. doi: 10.1007/s00261-018-1600-6. PubMed PMID:29730738 PubMed Central PMC6209534.
  13. Aherne, EA, Pak, LM, Goldman, DA, Gonen, M, Jarnagin, WR, Simpson, AL et al.. Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics?. Abdom Radiol (NY). 2018;43 (10):2665-2672. doi: 10.1007/s00261-018-1505-4. PubMed PMID:29492607 PubMed Central PMC6113129.
  14. Midya, A, Chakraborty, J, Gönen, M, Do, RKG, Simpson, AL. Influence of CT acquisition and reconstruction parameters on radiomic feature reproducibility. J Med Imaging (Bellingham). 2018;5 (1):011020. doi: 10.1117/1.JMI.5.1.011020. PubMed PMID:29487877 PubMed Central PMC5812985.
  15. Pak, LM, Chakraborty, J, Gonen, M, Chapman, WC, Do, RKG, Groot Koerkamp, B et al.. Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort. J. Am. Coll. Surg. 2018;226 (5):835-843. doi: 10.1016/j.jamcollsurg.2018.02.001. PubMed PMID:29454098 PubMed Central PMC5924623.
  16. Attiyeh, MA, Chakraborty, J, Doussot, A, Langdon-Embry, L, Mainarich, S, Gönen, M et al.. Survival Prediction in Pancreatic Ductal Adenocarcinoma by Quantitative Computed Tomography Image Analysis. Ann. Surg. Oncol. 2018;25 (4):1034-1042. doi: 10.1245/s10434-017-6323-3. PubMed PMID:29380093 .
  17. Heiselman, JS, Clements, LW, Collins, JA, Weis, JA, Simpson, AL, Geevarghese, SK et al.. Characterization and correction of intraoperative soft tissue deformation in image-guided laparoscopic liver surgery. J Med Imaging (Bellingham). 2018;5 (2):021203. doi: 10.1117/1.JMI.5.2.021203. PubMed PMID:29285519 PubMed Central PMC5729961.
  18. Chakraborty, J, Langdon-Embry, L, Cunanan, KM, Escalon, JG, Allen, PJ, Lowery, MA et al.. Preliminary study of tumor heterogeneity in imaging predicts two year survival in pancreatic cancer patients. PLoS ONE. 2017;12 (12):e0188022. doi: 10.1371/journal.pone.0188022. PubMed PMID:29216209 PubMed Central PMC5720792.
  19. Pak, LM, Gonen, M, Seier, K, Balachandran, VP, D'Angelica, MI, Jarnagin, WR et al.. Can physician gestalt predict survival in patients with resectable pancreatic adenocarcinoma?. Abdom Radiol (NY). 2018;43 (8):2113-2118. doi: 10.1007/s00261-017-1407-x. PubMed PMID:29177926 PubMed Central PMC5967975.
  20. Zheng, J, Chakraborty, J, Chapman, WC, Gerst, S, Gonen, M, Pak, LM et al.. Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Quantitative Image Analysis. J. Am. Coll. Surg. 2017;225 (6):778-788.e1. doi: 10.1016/j.jamcollsurg.2017.09.003. PubMed PMID:28941728 PubMed Central PMC5705269.
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