Johan Gagniere

Johan Gagniere

Johan Gagniere, MD, PhD

 

Profile:

I am studying oncologic outcomes and prognostic factors in BRAF mutant patients undergoing surgery for colorectal liver metastases. I also am studying the utility of a 3D image-guidance system in patients with intraoperative sonographically-occult colorectal liver metastases, and the interest of an intraoperative evaluation of the remnant pancreas perfusion using ICG to predict surgical outcomes after pancreatecomies. I obtained my medical degree from the University of Clermont-Auvergne, France in 2011, and I am now an attending HPB surgeon at the University Hospital of Clermont-Ferrand, France since 3 years. I obtained my Ph.D. degree at the U1071 INSERM unit, Clermont-Ferrand, France in 2017, where I am still working on the interactions between gut microbiota and colorectal cancer.


Funding Info:

1) University Hospital of Clermont-Ferrand Grant, France, for Cancer Research

2) Nuovo Soldati Foundation Grant for Cancer Research


Publications:

  1. Pak, LM, Gagnière, J, Allen, PJ, Balachandran, VP, D'Angelica, MI, DeMatteo, RP et al.. Utility of Image Guidance in the Localization of Disappearing Colorectal Liver Metastases. J. Gastrointest. Surg. 2019; :. doi: 10.1007/s11605-019-04106-2. PubMed PMID:30680630 .
  2. Vogin, G, Hettal, L, Vignaud, JM, Dartigues, P, Goere, D, Ferron, G et al.. Well-Differentiated Papillary Mesothelioma of the Peritoneum: A Retrospective Study from the RENAPE Observational Registry. Ann. Surg. Oncol. 2019;26 (3):852-860. doi: 10.1245/s10434-018-07153-2. PubMed PMID:30635798 .
  3. Rompteaux, P, Gagnière, J, Gornet, JM, Coriat, R, Baumgaertner, I, Lecomte, T et al.. Resection of small bowel adenocarcinoma metastases: Results of the ARCAD-NADEGE cohort study. Eur J Surg Oncol. 2019;45 (3):331-335. doi: 10.1016/j.ejso.2018.11.012. PubMed PMID:30501999 .
  4. Gagnière, J, Le Roy, B, Veziant, J, Pereira, B, Narayan, RR, Pezet, D et al.. Pancreaticoduodenectomy with right gastric vessels preservation: impact on intraoperative and postoperative outcomes. ANZ J Surg. 2018; :. doi: 10.1111/ans.14956. PubMed PMID:30497109 .
  5. Gagnière, J. HIPEC in the Elderly: A Meta-Analysis. Ann. Surg. Oncol. 2018;25 (Suppl 3):701-702. doi: 10.1245/s10434-018-6776-z. PubMed PMID:30242777 .
  6. Le Roy, B, Dupré, A, Gallon, A, Chabrot, P, Gagnière, J, Buc, E et al.. Liver hypertrophy: Underlying mechanisms and promoting procedures before major hepatectomy. J Visc Surg. 2018;155 (5):393-401. doi: 10.1016/j.jviscsurg.2018.03.005. PubMed PMID:30126801 .
  7. Gagnière, J, Dupré, A, Gholami, SS, Pezet, D, Boerner, T, Gönen, M et al.. Is Hepatectomy Justified for BRAF Mutant Colorectal Liver Metastases?: A Multi-institutional Analysis of 1497 Patients. Ann. Surg. 2018; :. doi: 10.1097/SLA.0000000000002968. PubMed PMID:29995686 .
  8. Malgras, B, Gayat, E, Aoun, O, Lo Dico, R, Eveno, C, Pautrat, K et al.. Impact of Combination Chemotherapy in Peritoneal Mesothelioma Hyperthermic Intraperitoneal Chemotherapy (HIPEC): The RENAPE Study. Ann. Surg. Oncol. 2018;25 (11):3271-3279. doi: 10.1245/s10434-018-6631-2. PubMed PMID:29978366 .
  9. Villéger, R, Lopès, A, Veziant, J, Gagnière, J, Barnich, N, Billard, E et al.. Microbial markers in colorectal cancer detection and/or prognosis. World J. Gastroenterol. 2018;24 (22):2327-2347. doi: 10.3748/wjg.v24.i22.2327. PubMed PMID:29904241 PubMed Central PMC6000297.
  10. Zaanan, A, Bouché, O, Benhaim, L, Buecher, B, Chapelle, N, Dubreuil, O et al.. Gastric cancer: French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO). Dig Liver Dis. 2018;50 (8):768-779. doi: 10.1016/j.dld.2018.04.025. PubMed PMID:29886081 .
  11. Courtot, L, Le Roy, B, Memeo, R, Voron, T, de Angelis, N, Tabchouri, N et al.. Risk factors for postoperative ileus following elective laparoscopic right colectomy: a retrospective multicentric study. Int J Colorectal Dis. 2018;33 (10):1373-1382. doi: 10.1007/s00384-018-3070-2. PubMed PMID:29732465 .
  12. Cohen, C, Tessier, W, Gronnier, C, Renaud, F, Pasquer, A, Théreaux, J et al.. Salvage Surgery for Esophageal Cancer: How to Improve Outcomes?. Ann. Surg. Oncol. 2018;25 (5):1277-1286. doi: 10.1245/s10434-018-6365-1. PubMed PMID:29417405 .
  13. Delhorme, JB, Severac, F, Averous, G, Glehen, O, Passot, G, Bakrin, N et al.. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin. Br J Surg. 2018;105 (6):668-676. doi: 10.1002/bjs.10716. PubMed PMID:29412465 .
  14. Gagnière, J, Poston, GJ, Boerner, T, Le Roy, B, Dupré, A. Unresectable Colorectal Liver Metastases: When Definitions Matter to Appropriately Assess Extreme Liver Resection Techniques. Ann. Surg. 2018;268 (6):e82-e83. doi: 10.1097/SLA.0000000000002677. PubMed PMID:29342016 .
  15. Scalabre, A, Philippe-Chomette, P, Passot, G, Orbach, D, Elias, D, Corradini, N et al.. Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: A French nationwide study over 14 years. Pediatr Blood Cancer. 2018;65 (4):. doi: 10.1002/pbc.26934. PubMed PMID:29286576 .
  16. Gagnière, J, Veziant, J, Pereira, B, Pezet, D, Le Roy, B, Slim, K et al.. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Elderly: Is It Reasonable? A Meta-Analysis. Ann. Surg. Oncol. 2018;25 (3):709-719. doi: 10.1245/s10434-017-6313-5. PubMed PMID:29282602 .
  17. Passot, G, Kim, BJ, Glehen, O, Mehran, RJ, Kopetz, SE, Goere, D et al.. Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?. Ann. Surg. Oncol. 2018;25 (1):179-187. doi: 10.1245/s10434-017-6141-7. PubMed PMID:29071660 .
  18. Alyami, M, Gagniere, J, Sgarbura, O, Cabelguenne, D, Villeneuve, L, Pezet, D et al.. Multicentric initial experience with the use of the pressurized intraperitoneal aerosol chemotherapy (PIPAC) in the management of unresectable peritoneal carcinomatosis. Eur J Surg Oncol. 2017;43 (11):2178-2183. doi: 10.1016/j.ejso.2017.09.010. PubMed PMID:28964609 .
  19. Markar, SR, Gronnier, C, Pasquer, A, Duhamel, A, Behal, H, Théreaux, J et al.. Discrepancy Between Clinical and Pathologic Nodal Status of Esophageal Cancer and Impact on Prognosis and Therapeutic Strategy. Ann. Surg. Oncol. 2017;24 (13):3911-3920. doi: 10.1245/s10434-017-6088-8. PubMed PMID:28948524 PubMed Central PMC5670185.
  20. Gagnière, J, Abjean, A, Franz, M, Aumont, O, Pereira, B, Dupré, A et al.. A Normal Preoperative Lipase Serum Level Is an Easy and Objective Risk Factor of Pancreatic Fistula After Pancreaticoduodenectomy. Pancreas. 2017;46 (9):1133-1140. doi: 10.1097/MPA.0000000000000905. PubMed PMID:28902783 .
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